ALAmax™ CR (120 Tablets)

Description

ALAmax™ CR provides whole-body, multifunctional antioxidant activity that helps to maintain healthy, well-functioning cells. ALAmax CR is designed to neutralize free radicals in both the water-based and lipid-based portion of cells, help the body synthesize glutathione, and recharge important antioxidants. In addition, biotin supports the function of alpha-lipoic acid in glucose metabolism.*

Discussion
Alpha-lipoic acid (ALA) is an eight-carbon disulfide water- and fat-soluble compound that is synthesized in small quantities in the liver
and other tissues. Oral supplementation readily crosses the blood brain barrier after it is absorbed in the small intestine, goes into the
portal vein, and is distributed via systemic circulation. Once in the tissues, ALA can be found inside and outside the cells including inside
the mitochondria where it functions naturally as a coenzyme for the oxidation of pyruvate, alpha ketoglutarate, and branched-chain amino acids.*
Researchers recently identified lipoic acid’s mechanisms of action related to maintaining metabolic health. It has a direct binding site at
the insulin receptor tyrosine kinase domain. ALA appears to modulate 5’-AMP-activated protein kinase and PPAR-regulated genes, to
activate PPAR–alpha and PPAR-gamma, and to support expression of PPAR-gamma mRNA and protein in heart tissue and smooth muscle of the aorta.*[2]
Controlled-release technology supports efficacy of alpha-lipoic acid in helping to maintain blood sugar already in the normal range.
Data from a 12-week clinical study indicate that supplementation with ALAmax™ CR (1200 mg per day, divided doses) may support
healthy C-peptide levels. C-peptide is used as an indication of insulin sensitivity.*[3,4]
Alpha-lipoic acid effectively neutralizes a variety of free radicals, including oxygen radicals and ionized metals. This action is particularly
beneficial for people who have higher levels of oxidative stress. Alpha lipoic acid regenerates vitamins C and E, increases tissue levels of
glutathione, and helps maintain the proper ratio of reduced to oxidized coenzyme Q10 in the mitochondria. In addition, alpha-lipoic acid may help the body rid itself of heavy metals.*
Healthy endothelial-mediated vasodilation is accepted as a surrogate marker for cardiovascular health and can be affected by synthesis,
bioavailability, or action of nitric oxide (NO). Increased oxidative stress appears to play a significant role in neutralizing or inactivating NO. ALA’s antioxidant properties, along with its demonstrated safety and potency, qualify it as a prime candidate to evaluate for its ability to support healthy endothelial function.*[5]
The ability of alpha-lipoic acid to improve energy metabolism and decrease oxidative stress alludes to its ability to support healthy
mitochondrial function with age.*
Biotin has been added because chronic administration of lipoic acid
lowers the activities of pyruvate carboxylase and beta-methylcrotonyl-CoA carboxylase in vivo by competing with biotin.*[6]

DIRECTIONS: Take one tablet 30 minutes before breakfast and one tablet 30 minutes before dinner, or as directed by your healthcare professional. Consult your healthcare professional prior to use. Individuals taking medication should discuss potential interactions with their healthcare professional. Do not use if tamper seal is damaged.

STORAGE: Keep closed in a cool, dry place out of reach of children.

Other Ingredients

FORMULATED TO EXCLUDE: Wheat, gluten, yeast, corn, soy, animal and dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, and artificial preservatives.

References
1. Teichert J, Kern J, Tritschler HJ, Ulrich H, Preiss R: Investigations on the pharmacokinetics of alpha-lipoic acid in healthy volunteers. Int.J.Clin. Pharmacol.Ther. 36:625-628, 1998
2. Pershadsingh HA. Alpha-lipoic acid: physiologic mechanisms and indications for the treatment of metabolic syndrome. Expert Opin Investig Drugs. 2007 Mar;16(3):291-302 [PMID: 17302524]
3. Evans JL, Goldfine ID: α-Lipoic acid: a multi-functional antioxidant that improves insulin sensitivity in patients with type 2 diabetes. Diabetes Technol Therap 2:401-413, 2000
4. Jacob S, Ruus P, et al. Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type 2 diabetes mellitus: a placebo-controlled pilot trial. Free Radic Biol Med 27:309-314, 1999
5. Bojunga J, et al. Antioxidative treatment reverses imbalances of nitric oxide synthase isoform expression and attenuates tissue-cGMP activation in diabetic rats. Biochem Biophys Res Commun. 2004 Apr 9;316(3):771-80 [PMID: 15033467]
6. Zempleni J, Trusty TA, Mock DM. Lipoic acid reduces the activities of biotin dependent carboxylases in rat liver. J Nutr. 1997 Sep;127(9):1776-81 [PMID: 9278559]
7. Foster TS. Efficacy and safety of {alpha}-lipoic acid supplementation in the treatment of symptomatic diabetic neuropathy. Diabetes Educ. 2007 JanFeb;33(1):111-7 [PMID: 17272797]
8. Alpha Lipoic Acid. www.naturaldatabase.com {accessed 3.06.07}
9. Diesel B. et. al. Alpha-lipoic acid as a directly binding activator of the insulin receptor: protection from hepatocyte apoptosis. Biochemistry. 2007 Feb 27;46(8):2146-2155. Epub 2007 Feb 3 [PMID: 17274632]

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.